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Our results highlight the opportunity of exploiting TOP1 inhibition to be coupled with CX-5461 as a non-genotoxic approach in concentrating on HR-proficient HGSC.Perturbational screens in these cell traces have also enthusiastic the event of EZH2 inhibitors in pediatric rhabdoid tumors9 and BRD4 inhibitors in neuroblastoma10,eleven. Even so, the ra